In this lab, we believe: science is real, love is love, black lives matter, feminism is for everyone, fish are cool, immigrants are welcome
Poster by Sammy Katta

Aim

We want to create a blueprint that describes how the range of actions of a developing animal organize dynamically to produce adaptive interactions with the environment. Put another way, we want to understand how behaviour unfolds early in life.

To achieve this task, we study the zebrafish since they develop externally and are genetically amenable. They can be raised and observed in a fully controlled environment and the size of embryos and larvae makes it easier to investigate early actions using computer-vision-based methods. On top we can visualize and interfere with specific cell populations in the brain and the periphery whilst the animal is still alive.

Primary approaches

Analyses of spontaneous activity and responses to stimuli to specify the ontogeny of random and goal directed actions.
Endocrinology to identify pathways that transform early signals outside the body into changes in bodily function.
Imaging and non-invasive optogenetics to study modulatory actions by specific cell populations.

A reference zebrafish larva reconstructed from multiple registered 3D images, Brainbow in the visual system and brainstem, and fluorescent expression in various fibers
Images by Ulrich Herget

Also

I like to bring ideas and people together and continue to be engaged in projects on learning and group behaviour.

Interested in joining the lab?

Leave me a message or email me directly with a CV (R.J.DeMarco@ljmu.ac.uk). You will join a great community at LJMU.